Sacrificio itself is many different books in one: a pandemic story, an intricate portrait of queer love, and a fever dream of place, time, and desire. Perhaps above all, Sacrificio is a spy novel that—like Lauren Wilkinson’s American Spy (2019) or Denis Johnson’s Tree of Smoke (2007)—redefines what a spy novel can be . . . Here, the spies, counterspies, secret police, and insurgents are people at the margins, those whom society has rejected and forgotten. For Los Injected Ones, a body, even one that is faltering, one that is ostracized for carrying a disease, can catalyze a rebellion.